Defiance, MO Homes for Sale

Defiance (St. Charles County, MO) has 16 homes for sale on the MLS right now, at a median list price of $632,500. 49 homes sold here in the last 12 months at a median of $750,000.

Measured from MARIS MLS listings · updated November 10, 2026

Defiance housing market at a glance

16homes for sale now
$632,500median list price
$272median list price per sq ft
38median days on market (active)
3new listings in the last 30 days
5under contract or pending
49sold in the last 12 months
$750,000median sale price, last 12 months

Homes that sold in Defiance in the last year went for a median of $311 per square foot. They took a median of 19 days to sell.

Homes for sale in Defiance by price

Under $200K (0) $200K to $350K (1) $350K to $500K (0) $500K to $750K (12) $750K and up (3)

See all 16 homes for sale in Defiance →

Newest listings in Defiance

800 Matson Hill Road, Unincorporated, MO, 63341
Active
MLS#26071517

$599,000

800 Matson Hill Road, Unincorporated, MO, 63341

  • 4 Bed

  • 3 Bath

  • 2,479 Sqft

Enjoy privacy and scenic views on approximately 8.25 wooded acres along Matson Hill Road in Unincorporated St. Charles County within the desirable Francis Howel...

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30 Wilderness Lane, Unincorporated, MO, 63341
Coming Soon
MLS#26070985

$525,000

30 Wilderness Lane, Unincorporated, MO, 63341

  • 4 Bed

  • 3 Bath

  • 2,845 Sqft

Professional pictures to come. Nestled on a quiet, wooded court, this rustic ranch offers almost 1900 square feet of warm, comfortable main floor living, with...

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410 Redeemer Court, Unincorporated, MO, 63341
Active
MLS#26069303

$1,249,900

410 Redeemer Court, Unincorporated, MO, 63341

  • 3 Bed

  • 3 Bath

  • 3,608 Sqft

Brand new custom-built home on 3+ wooded acres in Kohler Estates subdivision. Features 3 bedrooms and 3 1/2 baths, a oversized 3 car garage, a 3 car detached ga...

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601 Callaway Ridge Drive, Unincorporated, MO, 63341
Active
MLS#26063364

$549,900

601 Callaway Ridge Drive, Unincorporated, MO, 63341

  • 4 Bed

  • 4 Bath

  • 3,139 Sqft

Welcome to 601 Callaway Ridge Drive, where spacious ranch-style living meets the relaxed lifestyle of a lake community! This inviting home offers a desirable ra...

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229 Quail Run Drive, Unincorporated, MO, 63341
Active
MLS#26064475

$675,000

229 Quail Run Drive, Unincorporated, MO, 63341

  • 3 Bed

  • 3 Bath

  • 2,760 Sqft

Escape the ordinary and discover your own private retreat on 4.67 beautiful acres in the heart of Defiance, Missouri! Surrounded by mature trees and picturesque...

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1415 Highway F, Unincorporated, MO, 63341
Active
MLS#26043468

$700,000

1415 Highway F, Unincorporated, MO, 63341

  • 3 Bed

  • 2 Bath

  • 2,634 Sqft

Take a look and step back in time with this beautiful historic home in Defiance, Missouri. This home was built in 1886 and is situated on approximately 10 pictu...

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104 Wolf Trail Court, Unincorporated, MO, 63341
Active
MLS#26062370

$779,900

104 Wolf Trail Court, Unincorporated, MO, 63341

  • 4 Bed

  • 4 Bath

  • 4,937 Sqft

Great opportunity in a desirable Defiance location! This home offers the chance to add your own style and build equity with some updating and a little vision. S...

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2 Patrick Lane, Unincorporated, MO, 63341
Active
MLS#26054878

$739,900

2 Patrick Lane, Unincorporated, MO, 63341

  • 4 Bed

  • 4 Bath

  • 4,044 Sqft

SELLER IS OFFERING A $10,000 CREDIT to buyer at closing - can be used towards closing costs or a rate buydown! Space, Acreage & Garage Galore! Nestled on just o...

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What is for sale in Defiance

Of the homes for sale now: 100% single family residence.

By bedrooms: 3 bedrooms 7; 4 bedrooms 8; 5+ bedrooms 1 .

The median home for sale here was built in 1987 and has about 2,346 finished square feet above grade.

School districts on Defiance listings

School districts named on homes for sale in Defiance right now, with how many listings name each:

Francis Howell R-III (15)Washington (1)

From MLS listing data. Boundaries can change; confirm with the district for a specific address.

Subdivisions with homes for sale in Defiance

Ridgecreek Estate (1)Wilderness #2 (1)Centennial Farms #1 (1)Callaway Farms #3 (1)Callaway Farms #4 (1)Old Colony Farms (1)Callaway Farms #2 (1)Callaway Farms #5 (1)Callaway Valley #2 (1)Country Oaks #4 (1)Kohler Estates #1 (1)Wilderness #3 (1)

Defiance ZIP codes

63341 homes for sale

More communities in St. Charles County, MO

St. Charles (273 for sale)O'Fallon (301 for sale)St. Peters (115 for sale)Wentzville (233 for sale)Lake St Louis (95 for sale)Dardenne Prairie (51 for sale)Foristell (37 for sale)Cottleville (21 for sale)Weldon Spring (22 for sale)St. Paul (4 for sale)Augusta (10 for sale)New Melle (14 for sale)

All St. Charles County, MO homes for sale · Every St. Louis area community

Defiance real estate questions

What is the median list price of homes for sale in Defiance, MO?

The median list price of the 16 homes for sale in Defiance is $632,500, or about $272 per square foot, based on MLS listings as of November 10, 2026.

What did homes sell for in Defiance, MO in the last year?

49 homes sold in Defiance in the last 12 months. The median sale price reported to the MLS was $750,000.

How long are homes in Defiance, MO on the market?

Active listings in Defiance have been on the market a median of 38 days, and homes that sold in the last 12 months took a median of 19 days.

What school districts are homes for sale in Defiance, MO in?

Current Defiance listings name these school districts: Francis Howell R-III, Washington. Confirm boundaries with the district for a specific address.

Own a home in Defiance?

See what it could sell for, with the recent sales behind the number.

What’s my home worth? Off-market & sold homes

Statistics cover residential listings in MARIS MLS, computed November 10, 2026. Sale prices are as reported to the MLS. Listing data is deemed reliable but is not guaranteed. StLouisRealEstate.com is operated by Guerrilla Brokers, LLC.