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221 W Saint Joseph Street, Perryville, MO, 63775

Looking for a turn key, fully operational business in the heart of Perryville? The Mediterranean House presents a rare opportunity to own a luxury property designed to host unforgettable stays and events. Currently operating as a successful and versatile venue, this property is well suited for use as an Airbnb, bed and breakfast, or a destination for corporate retreats, wellness or yoga getaways, and private events. The home features six beautifully appointed bedrooms, four full bathrooms, and one half bathroom, offering ample accommodations for guests. A commercial grade kitchen equipped with stainless steel appliances is ready to support culinary experiences, from baking and cooking workshops to catered events. All furniture stays, including antique furnishings, bedroom suites, dining room suites, etc. With its flexible layout and elegant setting, The Mediterranean House is ideal for bridal and baby showers, birthday celebrations, intimate gatherings, or larger hosted events. This is a truly turn key business opportunity, ready for immediate operation, offering the space, functionality, and charm to bring a wide range of visions to life.

Status: Active · MLS# 25081439 · Listing Courtesy of EDGE Realty ERA Powered, [email protected]

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Subdivision: Fifth Principal Meridian

List Price

$ 560,000

Status

Active

Days on market

0

MLS#

25081439

Bedrooms

6

Full baths

5

Sq. Ft. Above

3,143

Subdivision

Fifth Principal Meridian

School District

Perry Co. 32

County

Perry

Property Type

Residential

Style

Historic

Type

Residential

Additional Information

Property Tax (2025)

$4,078

Recent Nearby Sales in 63775

Last 6 closed homes in this zip.

Address Bd/Ba SqFt List Sold Closed
680 Kiefner Street, Perryville, MO 63775 3/3 1,831 $469,000 $469,000
100% of ask
Nov 10, 2026
56 Saint Johns Court, Perryville, MO 63775 3/2 960 $210,000 $208,000
99% of ask
Nov 6, 2026
1626 Pcr 730, Perryville, MO 63775 4/2 1,819 $389,900 $387,900
99.5% of ask
Nov 6, 2026
2759 Pcr 910, Perryville, MO 63775 3/2 2,208 $1,498,000 $1,498,000
100% of ask
Oct 30, 2026
7617 Highway O, Perryville, MO 63775 3/3 1,620 $350,000 $355,000
101.4% of ask
Oct 26, 2026
704 Kingshighway St, Perryville, MO 63775 0/0 -- $125,000 $85,000
68% of ask
Oct 26, 2026

Price & Listing History

Listed for sale
Dec 16, 2025 at $560,000
Current status: Active
As of Oct 20, 2026 · $560,000

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