Homes for Sale in East Prairie, MO (63845)

Browse every active MARIS IDX listing in East Prairie, MO (zip code 63845). Updated every 15 minutes from MLS Grid. Currently showing 31 active IDX listings.

31 active listings updated every 5 minutes

Featured Listings

 000 CR 706, 2, East Prairie, MO, 63845
Active
MLS#26020639

$1,358,810

000 CR 706, 2, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

This productive row crop farm, spanning approximately 160+/- acres across the New Madrid and Mississippi County line in Missouri, represents a quality agricultu...

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200 Margaret Drive, East Prairie, MO, 63845
Active
MLS#25064529

$195,000

200 Margaret Drive, East Prairie, MO, 63845

  • 2 Bed

  • 2 Bath

  • 1,888 Sqft

This beautiful home sits right outside city limits in a very desirable neighborhood! This 2 bedroom 2 bath home has a semi open floor plan and a great flow! T...

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3215 S Hwy 105, East Prairie, MO, 63845
Active
MLS#26054617

$260,000

3215 S Hwy 105, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 1,440 Sqft

This house has it all! This beautiful 3 bedroom 2 bath home was built with all of the details in mind so let's go over them! All energy efficient options were...

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000 State Highway 80, 5, East Prairie, MO, 63845
Active
MLS#26020676

$4,570,410

000 State Highway 80, 5, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

This productive row crop farm, 460+/- acres just east of East Prairie in Mississippi County Missouri, represents a high-quality agricultural asset with excellen...

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308 E Pine St, East Prairie, MO, 63845
Active
MLS#26030679

$149,900

308 E Pine St, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 0 Sqft

Take a look at the open concept 3 bed 2 bath home! This low maintenance home was built in 2018 and located close to the downtown shops! Perfect for a family loo...

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213 Lombardy Dr, East Prairie, MO, 63845
Active
MLS#26049663

$130,000

213 Lombardy Dr, East Prairie, MO, 63845

  • 2 Bed

  • 1 Bath

  • 1,546 Sqft

Looking for a great starter home in an excellent neighborhood!? Here is is! This home sits on a corner lot with access to Lombardy and also to Millar Rd. Whe...

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409 N Martin, East Prairie, MO, 63845
Active
MLS#26008726

$125,000

409 N Martin, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

Looking for your next investment property?! Looking to start your investment portfolio!? I have the ideal property for you!! This 6 unit storage facility was...

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205 Maxine, East Prairie, MO, 63845
Active
MLS#26014681

$17,900

205 Maxine, East Prairie, MO, 63845

  • 3 Bed

  • 1 Bath

  • 1,194 Sqft

**Seller will consider Owner-Financing.** This 3-bedroom, 1-bathroom home is ready for new owners. A covered, screened-in front porch and a covered back porch...

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410 S Martin, East Prairie, MO, 63845
Active
MLS#26049363

$215,000

410 S Martin, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 1,861 Sqft

Beautiful bungalow that sits on a corner lot and has been completely remodeled. This home offers 3 bedrooms and 2 full bathrooms. If you love to entertain than...

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000 County Road 507, East Prairie, MO, 63845
Active
MLS#26062103

$4,500,000

000 County Road 507, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

Premier 440 +/- Acres in the Wolf Island Region of Mississippi County, Missouri This premier Mississippi County property offers an exceptional opportunity to a...

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40 Alesia Dr, East Prairie, MO, 63845
Active
MLS#26042599

$379,000

40 Alesia Dr, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 2,909 Sqft

This one has it all and move in ready! Beautiful big main home, in ground pool and pool house, 2 shops, corner lot, and excellent location!!! This home is per...

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000 County Road 512, East Prairie, MO, 63845
Active
MLS#26062121

$800,000

000 County Road 512, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

Premium 80 +/- Acre Irrigated Farmland in Mississippi County, MO Here’s an incredible opportunity to purchase a premium 80-acre agricultural tract in the reno...

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280 Atlantic Ln, East Prairie, MO, 63845
Active
MLS#26038056

$279,000

280 Atlantic Ln, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 2,010 Sqft

This beautiful country home is seeking new owners!! You immediately feel the warmth when you walk up to the front porch which spans the length of the home! As...

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319 Clay Morgan Dr, East Prairie, MO, 63845
Active
MLS#25042859

$285,000

319 Clay Morgan Dr, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

Looking for a great commercial building with a ton of space and almost 2 acres! Here it is!!!! This location sits right outside the city limits of East Prairi...

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2128 W 416th Road, East Prairie, MO, 63845
Active
MLS#26058420

$339,500

2128 W 416th Road, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

Welcome to this impressive rural property in the heart of Mississippi County's productive farmland. Nestled along W. 416th Road just outside East Prairie. Thi...

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308 Folk, East Prairie, MO, 63845
Active
MLS#26046187

$160,000

308 Folk, East Prairie, MO, 63845

  • 3 Bed

  • 1 Bath

  • 1,092 Sqft

Looking for a fully remodeled home, move in ready!?!?! I have it!! When I say fully remodeled I mean, new flooring, new kitchen, new bathroom, new lighting, n...

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95 Luke Morgan LN, East Prairie, MO, 63845
Active
MLS#26061825

$239,000

95 Luke Morgan LN, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 1,806 Sqft

Move in Ready!!! This home sits in an excellent neighborhood with a wonderful layout!! This 3 bedroom 2 full bath home sits on an acre of land outside city li...

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180 Luke Morgan Lane, East Prairie, MO, 63845
Active
MLS#26048853

$165,000

180 Luke Morgan Lane, East Prairie, MO, 63845

  • 2 Bed

  • 1 Bath

  • 1,200 Sqft

Welcome to 180 Luke Morgan Lane in East Prairie! Sitting on approximately 1.05 acres, this 2 bedroom, 1 bath home offers 1200 square feet of comfortable living...

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355 Margaret Dr, East Prairie, MO, 63845
Active
MLS#26053130

$235,000

355 Margaret Dr, East Prairie, MO, 63845

  • 3 Bed

  • 2 Bath

  • 1,408 Sqft

Call me today to tour this amazing home! This 3 bedroom 2 bath home is ready for its next owners! You will immediately feel at home with the beautiful wood fl...

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0 S Highway BB, East Prairie, MO, 63845
Active
MLS#26030953

$918,000

0 S Highway BB, East Prairie, MO, 63845

  • 0 Bed

  • 0 Bath

  • 0 Sqft

New to the market! +/- 101.94 acres of Farmland for Sale – Prime Agricultural Investment Opportunity Discover this exceptional tract of productive farmland s...

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961 S 413th Rd, East Prairie, MO, 63845
Active
MLS#26057564

$359,000

961 S 413th Rd, East Prairie, MO, 63845

  • 5 Bed

  • 5 Bath

  • 2,813 Sqft

Have you been looking for a move in ready home with a ton of space!?!?!? This is it!!! Completely redone and ready to impress! This stunning 5-bedroom, 5-bath...

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20 & 30 Artic Lane, East Prairie, MO, 63845
Active
MLS#25036516

$175,000

20 & 30 Artic Lane, East Prairie, MO, 63845

  • 3 Bed

  • 1 Bath

  • 1,158 Sqft

One of a kind property for sale!!!! Property sits in an extremely desirable location know as Dogwood right outside East Prairie. This property is 1.5 acres an...

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280 County Highway 812, East Prairie, MO, 63845
Active
MLS#26057403

$75,000

280 County Highway 812, East Prairie, MO, 63845

  • 4 Bed

  • 2 Bath

  • 2,335 Sqft

This 4 bedroom, 2 bathroom home is located just south of Dogwood. There is over 2,300 square feet of living space and sits on a nice lot. Great opportunity to p...

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2128 W 416th Road, East Prairie, MO, 63845
Active
MLS#26058175

$339,500

2128 W 416th Road, East Prairie, MO, 63845

  • 1 Bed

  • 1 Bath

  • 900 Sqft

Welcome to this impressive rural property in the heart of Mississippi County's productive farmland. Nestled along W. 416th Road just outside East Prairie. Thi...

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About East Prairie, MO (63845)

East Prairie in Mississippi County sits in the bootheel of Missouri, roughly 150 miles south of St. Louis near the Arkansas and Tennessee borders. This rural area is characterized by farmland, small-town living, and a slower pace of life typical of Southeast Missouri. The region offers affordability and space, making it attractive to buyers seeking land and lower cost of living, though job markets and amenities are more limited than urban areas.

Buyers relocating to 63845 should understand this is primarily agricultural country with a small-town feel. The area is significantly distant from major St. Louis metros and employment centers, so it's best suited for remote workers, retirees, or those with local ties.

Market Overview

The 63845 zip code market spans a wide range, with current listings between $24,900 and $4,570,410, reflecting everything from affordable starter homes and vacant land to larger rural properties and acreage. Most homes in this area tend to be modest residential properties and farmland rather than new construction or luxury developments. This is a buyer's market with limited competition, appealing primarily to value-conscious buyers, investors in rural land, or those seeking agricultural properties.

Schools

Schools in this area include several districts within Mississippi County -- check with the listing agent for the specific school assignment for any address.

Neighborhoods & Subdivisions

Residential areas in zip code 63845 include neighborhoods such as Eastland School Addition, Van Marshall, Nelsons Second Addition, and Gilliams Addition, along with non-subdivided properties throughout the area. Most of the residential character is rural and dispersed rather than concentrated in formal subdivisions, with homes scattered across the landscape typical of Southeast Missouri bootheel communities.

About Mississippi County

Zip code 63845 is located in Mississippi County. Refine your search by price, beds, baths and more using the filters above the listings grid.

Communities and Cities Within

East Prairie

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Disclaimer: Listings courtesy of MARIS MLS as distributed by MLS GRID. The information on this site is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The information contained herein is deemed reliable but is not guaranteed by MLS GRID, MARIS, Guerrilla Brokers, LLC or the owner of this website. The listing information shown herein is based on information submitted to the MLS GRID as of 09/30/2026 12:45 PM. All data is obtained from various sources and may not have been verified by MLS GRID, MARIS, Guerrilla Brokers, LLC or the owner of this website. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

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